Jump to main content
Jump to site search

Issue 10, 2020
Previous Article Next Article

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

Author affiliations

Abstract

Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this paper, we describe the identification of a 6-amino-N-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine scaffold and its optimization to give compounds which showed efficacy when orally dosed in a mouse model of VL.

Graphical abstract: Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

Back to tab navigation

Supplementary files

Article information


Submitted
12 Jun 2020
Accepted
07 Jul 2020
First published
06 Aug 2020

This article is Open Access

RSC Med. Chem., 2020,11, 1168-1177
Article type
Research Article

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis

M. G. Thomas, M. De Rycker, M. Ajakane, S. D. Crouch, L. Campbell, A. Daugan, G. Fra, C. Guerrero, C. J. Mackenzie, L. MacLean, S. Manthri, F. Martin, S. Norval, M. Osuna-Cabello, J. Riley, Y. Shishikura, J. Miguel-Siles, F. R. C. Simeons, L. Stojanovski, J. Thomas, S. Thompson, R. F. Velasco, J. M. Fiandor, P. G. Wyatt, K. D. Read, I. H. Gilbert and T. J. Miles, RSC Med. Chem., 2020, 11, 1168
DOI: 10.1039/D0MD00203H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements