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Issue 9, 2019
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Emerging modes-of-action in drug discovery

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Abstract

An increasing focus on complex biology to cure diseases rather than merely treat symptoms has transformed how drug discovery can be approached. Instead of activating or blocking protein function, a growing repertoire of drug modalities can be leveraged or engineered to hijack cellular processes, such as translational regulation or degradation mechanisms. Drug hunters can therefore access a wider arsenal of modes-of-action to modulate biological processes and this review summarises these emerging strategies by highlighting the most representative examples of these approaches.

Graphical abstract: Emerging modes-of-action in drug discovery

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Article information


Submitted
08 May 2019
Accepted
21 Jun 2019
First published
25 Jun 2019

Med. Chem. Commun., 2019,10, 1550-1568
Article type
Review Article

Emerging modes-of-action in drug discovery

E. Valeur, F. Narjes, C. Ottmann and A. T. Plowright, Med. Chem. Commun., 2019, 10, 1550 DOI: 10.1039/C9MD00263D

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