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Issue 8, 2019
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Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes

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Abstract

A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.

Graphical abstract: Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes

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Article information


Submitted
18 Apr 2019
Accepted
12 Jun 2019
First published
17 Jul 2019

Med. Chem. Commun., 2019,10, 1432-1437
Article type
Research Article

Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes

H. Yamamura, K. Isshiki, Y. Fujita, H. Kato, T. Katsu, K. Masuda, K. Osawa and A. Miyagawa, Med. Chem. Commun., 2019, 10, 1432
DOI: 10.1039/C9MD00229D

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