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Issue 9, 2019

Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

Author affiliations

Abstract

Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The development of inhibitors of the enzyme dihydrodipicolinate synthase (DHDPS), which is involved in the diaminopimelate pathway, represents an attractive approach to the discovery of new antibacterial agents. Herein, the challenges and opportunities of DHDPS inhibitors are discussed.

Graphical abstract: Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

Supplementary files

Article information


Submitted
21 Feb 2019
Accepted
04 Jul 2019
First published
15 Jul 2019

Med. Chem. Commun., 2019,10, 1581-1588
Article type
Review Article

Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target

R. M. Christoff, C. K. Gardhi, T. P. Soares da Costa, M. A. Perugini and B. M. Abbott, Med. Chem. Commun., 2019, 10, 1581 DOI: 10.1039/C9MD00107G

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