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Issue 11, 2018
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Benzophenone: a ubiquitous scaffold in medicinal chemistry

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The benzophenone scaffold represents a ubiquitous structure in medicinal chemistry because it is found in several naturally occurring molecules which exhibit a variety of biological activities, such as anticancer, anti-inflammatory, antimicrobial, and antiviral. In addition, various synthetic benzophenone motifs are present in marketed drugs. They also represent important ingredients in perfumes and can act as photoinitiators. This review will provide an overview of benzophenone moieties with medicinal aspects synthesized in the last 15 years and will cover the most potent molecule in each report. In this review, only benzophenones with substitutions on their aryl rings, i.e. diphenyl ketone analogues, have been covered.

Graphical abstract: Benzophenone: a ubiquitous scaffold in medicinal chemistry

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Publication details

The article was received on 13 Jun 2018, accepted on 23 Aug 2018 and first published on 23 Aug 2018

Article type: Review Article
DOI: 10.1039/C8MD00300A
Citation: Med. Chem. Commun., 2018,9, 1803-1817

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    Benzophenone: a ubiquitous scaffold in medicinal chemistry

    K. Surana, B. Chaudhary, M. Diwaker and S. Sharma, Med. Chem. Commun., 2018, 9, 1803
    DOI: 10.1039/C8MD00300A

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