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Issue 11, 2018
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Benzophenone: a ubiquitous scaffold in medicinal chemistry

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Abstract

The benzophenone scaffold represents a ubiquitous structure in medicinal chemistry because it is found in several naturally occurring molecules which exhibit a variety of biological activities, such as anticancer, anti-inflammatory, antimicrobial, and antiviral. In addition, various synthetic benzophenone motifs are present in marketed drugs. They also represent important ingredients in perfumes and can act as photoinitiators. This review will provide an overview of benzophenone moieties with medicinal aspects synthesized in the last 15 years and will cover the most potent molecule in each report. In this review, only benzophenones with substitutions on their aryl rings, i.e. diphenyl ketone analogues, have been covered.

Graphical abstract: Benzophenone: a ubiquitous scaffold in medicinal chemistry

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Article information


Submitted
13 Jun 2018
Accepted
23 Aug 2018
First published
23 Aug 2018

Med. Chem. Commun., 2018,9, 1803-1817
Article type
Review Article

Benzophenone: a ubiquitous scaffold in medicinal chemistry

K. Surana, B. Chaudhary, M. Diwaker and S. Sharma, Med. Chem. Commun., 2018, 9, 1803
DOI: 10.1039/C8MD00300A

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