Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 4, 2018
Previous Article Next Article

Crystallomycin revisited after 60 years: aspartocins B and C

Author affiliations


The study of an archived sample of crystallomycin complex using HPLC, ESI HRMS, and 2D NMR showed that two major components of the antibiotic, compounds 1 and 2, are lipopeptides having the same peptide core, Asp1-cyclo(Dab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), N-acylated either with Δ3-iso-tetradecenoyl or Δ3-anteiso-pentadecenoyl that are identical to aspartocins C and B, respectively. According to the 2D NMR study, compound 2 in DMSO solution exists as a mixture of four conformers. The producing strain was identified as Streptomyces griseorubens. Compounds 1 and 2 have considerable Ca2+-dependent activity against Gram-positive bacteria including five MRSA strains.

Graphical abstract: Crystallomycin revisited after 60 years: aspartocins B and C

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Jan 2018, accepted on 25 Feb 2018 and first published on 27 Feb 2018

Article type: Research Article
DOI: 10.1039/C8MD00002F
Citation: Med. Chem. Commun., 2018,9, 667-675

  •   Request permissions

    Crystallomycin revisited after 60 years: aspartocins B and C

    A. P. Tyurin, V. A. Alferova, A. S. Paramonov, M. V. Shuvalov, I. A. Malanicheva, N. E. Grammatikova, P. N. Solyev, S. Liu, C. Sun, I. A. Prokhorenko, T. A. Efimenko, L. P. Terekhova, O. V. Efremenkova, Z. O. Shenkarev and V. A. Korshun, Med. Chem. Commun., 2018, 9, 667
    DOI: 10.1039/C8MD00002F

Search articles by author