Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 1, 2018
Previous Article Next Article

Narrow-spectrum antibacterial agents

Author affiliations


While broad spectrum antibiotics play an invaluable role in the treatment of bacterial infections, there are some drawbacks to their use, namely selection for and spread of resistance across multiple bacterial species, and the detrimental effect they can have upon the host microbiome. If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate some of these issues. This review outlines the advantages and challenges of narrow-spectrum antibacterial agents, discusses the progress that has been made toward developing diagnostics to enable their use, and describes some of the narrow-spectrum antibacterial agents currently being investigated against some of the most clinically important bacteria including Clostridium difficile, Mycobacterium tuberculosis and several ESKAPE pathogens.

Graphical abstract: Narrow-spectrum antibacterial agents

Back to tab navigation

Publication details

The article was received on 17 Oct 2017, accepted on 02 Nov 2017 and first published on 06 Nov 2017

Article type: Review Article
DOI: 10.1039/C7MD00528H
Citation: Med. Chem. Commun., 2018,9, 12-21

  •   Request permissions

    Narrow-spectrum antibacterial agents

    R. J. Melander, D. V. Zurawski and C. Melander, Med. Chem. Commun., 2018, 9, 12
    DOI: 10.1039/C7MD00528H

Search articles by author