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Issue 11, 2017

Benzisoxazole: a privileged scaffold for medicinal chemistry

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Abstract

The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.

Graphical abstract: Benzisoxazole: a privileged scaffold for medicinal chemistry

Article information


Submitted
01 Sep 2017
Accepted
05 Oct 2017
First published
31 Oct 2017

Med. Chem. Commun., 2017,8, 2023-2039
Article type
Review Article

Benzisoxazole: a privileged scaffold for medicinal chemistry

K. P. Rakesh, C. S. Shantharam, M. B. Sridhara, H. M. Manukumar and H. Qin, Med. Chem. Commun., 2017, 8, 2023 DOI: 10.1039/C7MD00449D

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