Issue 5, 2017

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

Abstract

A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and then fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.

Graphical abstract: Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

Supplementary files

Article information

Article type
Research Article
Submitted
05 Jan 2017
Accepted
07 Mar 2017
First published
10 Mar 2017

Med. Chem. Commun., 2017,8, 1015-1021

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

E. O. J. Porta, S. N. Jäger, I. Nocito, G. I. Lepesheva, E. C. Serra, B. L. Tekwani and G. R. Labadie, Med. Chem. Commun., 2017, 8, 1015 DOI: 10.1039/C7MD00008A

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