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Issue 9, 2016
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Anticancer agents interacting with membrane glucose transporters

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Abstract

The altered metabolism observed in cancer cells generally consists of increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of cancer cells. Therefore, GLUTs are considered as suitable targets for treatment of cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective anticancer agents.

Graphical abstract: Anticancer agents interacting with membrane glucose transporters

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Publication details

The article was received on 26 May 2016, accepted on 07 Jul 2016 and first published on 08 Jul 2016


Article type: Review Article
DOI: 10.1039/C6MD00287K
Citation: Med. Chem. Commun., 2016,7, 1716-1729
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    Anticancer agents interacting with membrane glucose transporters

    C. Granchi, S. Fortunato and F. Minutolo, Med. Chem. Commun., 2016, 7, 1716
    DOI: 10.1039/C6MD00287K

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