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Issue 10, 2016

Conjugated 5-fluorouracil with mitochondria-targeting lipophilic cation: design, synthesis and biological evaluation

Author affiliations

Abstract

5-Fluorouracil (5-FU) was linked with F16 by vulnerable bonds to selectively target cancer mitochondria which resulted in conjugated compounds, including F16–5-FU, F16–OOC-FU, F16–NHOC-FU and F16–SS-FU. F16–OOC-FU decreased the antiproliferative activity of 5-FU on the nontumor cell line, and the cytotoxicity of F16–SS-FU significantly increased when administered with dithiothreitol (DTT).

Graphical abstract: Conjugated 5-fluorouracil with mitochondria-targeting lipophilic cation: design, synthesis and biological evaluation

Supplementary files

Article information


Submitted
17 May 2016
Accepted
21 Jul 2016
First published
22 Jul 2016

Med. Chem. Commun., 2016,7, 2016-2019
Article type
Research Article

Conjugated 5-fluorouracil with mitochondria-targeting lipophilic cation: design, synthesis and biological evaluation

J. Wang, X. Fan, L. Yang, H. He, R. Huang, F. Jiang and Y. Liu, Med. Chem. Commun., 2016, 7, 2016 DOI: 10.1039/C6MD00268D

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