Jump to main content
Jump to site search

Issue 4, 2016
Previous Article Next Article

De novo design of helical peptides to inhibit tumor necrosis factor-α by disrupting its trimer formation

Author affiliations

Abstract

A computational strategy was used to design helical peptides that can bind to tumor necrosis factor-α (TNFα) dimers to prevent active trimer formation. Three designed peptides showed TNFα inhibition at the cellular level. Chemical crosslinking and mass spectrometry studies verified that these peptides function by breaking TNFα trimers.

Graphical abstract: De novo design of helical peptides to inhibit tumor necrosis factor-α by disrupting its trimer formation

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Nov 2015, accepted on 21 Jan 2016 and first published on 22 Jan 2016


Article type: Research Article
DOI: 10.1039/C5MD00549C
Author version
available:
Download author version (PDF)
Citation: Med. Chem. Commun., 2016,7, 725-729

  •   Request permissions

    De novo design of helical peptides to inhibit tumor necrosis factor-α by disrupting its trimer formation

    Q. Shen, C. Zhang, H. Liu, Y. Liu, J. Cao, X. Zhang, Y. Liang, M. Zhao and L. Lai, Med. Chem. Commun., 2016, 7, 725
    DOI: 10.1039/C5MD00549C

Search articles by author

Spotlight

Advertisements