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Issue 1, 2016
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Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

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Abstract

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.

Graphical abstract: Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

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Supplementary files

Article information


Submitted
18 Aug 2015
Accepted
18 Sep 2015
First published
30 Sep 2015

Med. Chem. Commun., 2016,7, 128-131
Article type
Concise Article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

M. D. Stephens, V. B. Hubble, R. K. Ernst, M. L. van Hoek, R. J. Melander, J. Cavanagh and C. Melander, Med. Chem. Commun., 2016, 7, 128
DOI: 10.1039/C5MD00353A

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