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Issue 1, 2015
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Rational design of protein–protein interaction inhibitors

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Protein–protein interactions are at the heart of most physiopathological processes. As such, they have attracted considerable attention for designing drugs of the future. Although initially considered as high-value but difficult to identify, low molecular weight compounds able to selectively and potently modulate protein–protein interactions have recently reached clinical trials. Along with high-throughput screening of compound libraries, combining structural and computational approaches has boosted this formerly minor area of research into a currently tremendously active field. This review highlights the very recent developments in the rational design of protein–protein interaction inhibitors.

Graphical abstract: Rational design of protein–protein interaction inhibitors

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The article was received on 30 Jul 2014, accepted on 22 Sep 2014 and first published on 23 Sep 2014

Article type: Review Article
DOI: 10.1039/C4MD00328D
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Med. Chem. Commun., 2015,6, 51-60

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    Rational design of protein–protein interaction inhibitors

    D. Rognan, Med. Chem. Commun., 2015, 6, 51
    DOI: 10.1039/C4MD00328D

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