Issue 9, 2014

Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

Abstract

A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose. Their effects on annexin V, DNA fragmentation, and the cell cycle, together with mitochondrial membrane permeabilization tests, provide insights into their mechanism of action. Also, experiments with A431 human epidermoid carcinoma cells suggest the activation of an apoptotic pathway, due to activity of the initiator caspase 8 and effector caspase 3.

Graphical abstract: Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

Supplementary files

Article information

Article type
Concise Article
Submitted
07 Apr 2014
Accepted
17 Jun 2014
First published
24 Jun 2014

Med. Chem. Commun., 2014,5, 1404-1409

Author version available

Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

S. V. Malhotra, V. Kumar, C. Velez and B. Zayas, Med. Chem. Commun., 2014, 5, 1404 DOI: 10.1039/C4MD00161C

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