Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2014
Previous Article Next Article

Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

Author affiliations

Abstract

In the past decade, scientific advances in network pharmacology have laid the foundations for a polypharmacological approach to discover new drugs for complex diseases. There is now a comprehensive understanding that many incurable diseases are multifactorial in nature and, consequently, conventional drugs directed to a single molecular target are inadequate. To achieve a desired clinical outcome, a polypharmacological approach seeks to intervene in the diseased network using either combinations of multiple drugs or single small molecules modulating multiple targets. Both these approaches are equally feasible from a clinical standpoint. However, for various reasons which will be discussed in this review, the latter approach may be favoured for Alzheimer's disease (AD) and neglected tropical diseases (NTDs). With each passing year, an increasing number of multitarget drugs and drug candidates are being identified, and several proof-of-concepts for treating these two diseases have emerged. Herein, with an awareness of the obstacles and challenges faced, we explore small molecules that seek to modulate multiple targets with the ultimate goal of harnessing network pharmacology for therapeutic applications in AD and NTDs.

Graphical abstract: Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

Back to tab navigation

Publication details

The article was received on 19 Feb 2014, accepted on 15 Mar 2014 and first published on 17 Mar 2014


Article type: Review Article
DOI: 10.1039/C4MD00069B
Author version
available:
Download author version (PDF)
Citation: Med. Chem. Commun., 2014,5, 853-861

  •   Request permissions

    Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

    F. Prati, E. Uliassi and M. L. Bolognesi, Med. Chem. Commun., 2014, 5, 853
    DOI: 10.1039/C4MD00069B

Search articles by author

Spotlight

Advertisements