Jump to main content
Jump to site search

Issue 5, 2014
Previous Article Next Article

Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study

Author affiliations

Abstract

A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose–response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers.

Graphical abstract: Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study

Back to tab navigation

Supplementary files

Article information


Submitted
31 Dec 2013
Accepted
07 Feb 2014
First published
11 Feb 2014

Med. Chem. Commun., 2014,5, 576-586
Article type
Concise Article
Author version available

Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study

A. Thakur, S. Manohar, C. E. Vélez Gerena, B. Zayas, V. Kumar, S. V. Malhotra and D. S. Rawat, Med. Chem. Commun., 2014, 5, 576
DOI: 10.1039/C3MD00399J

Search articles by author

Spotlight

Advertisements