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Issue 4, 2014
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Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

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Abstract

The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([18F]FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuous-flow microfluidics device. This work represents the first positron emission tomography (PET) radiopharmaceutical that is suitable for human use with this technology. We also describe a validated synthesis of [18F]FPEB with a commercial reactor-based system.

Graphical abstract: Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

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Publication details

The article was received on 31 Oct 2013, accepted on 03 Dec 2013 and first published on 11 Dec 2013


Article type: Concise Article
DOI: 10.1039/C3MD00335C
Med. Chem. Commun., 2014,5, 432-435

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    Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

    S. H. Liang, D. L. Yokell, R. N. Jackson, P. A. Rice, R. Callahan, K. A. Johnson, D. Alagille, G. Tamagnan, T. Lee Collier and N. Vasdev, Med. Chem. Commun., 2014, 5, 432
    DOI: 10.1039/C3MD00335C

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