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Issue 7, 2014
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Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy

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Abstract

Generation 5 poly(amidoamine) dendrimers were used as a nanoplatform to conjugate covalently an anticancer drug, alpha-tocopheryl succinate (α-Tos) and targeting ligand folic acid (FA). The formed multifunctional dendrimers are able to endow the hydrophobic drug α-Tos with improved water solubility for targeted inhibition of cancer cells via an FA receptor-mediated targeting pathway.

Graphical abstract: Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy

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Publication details

The article was received on 27 Oct 2013, accepted on 28 Jan 2014 and first published on 29 Jan 2014


Article type: Concise Article
DOI: 10.1039/C3MD00324H
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Citation: Med. Chem. Commun., 2014,5, 879-885
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    Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy

    Y. Zheng, F. Fu, M. Zhang, M. Shen, M. Zhu and X. Shi, Med. Chem. Commun., 2014, 5, 879
    DOI: 10.1039/C3MD00324H

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