Issue 7, 2014
From the journal:

MedChemComm

Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy†

Yun Zheng,‡ab   Fanfan Fu,‡b   Mengen Zhang,a   Mingwu Shen,*a   Meifang Zhub  and  Xiangyang Shi*ab  

* Corresponding authors

a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, People's Republic of China
E-mail: mingwu_shen@yahoo.com, xshi@dhu.edu.cn

b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China

Abstract

Generation 5 poly(amidoamine) dendrimers were used as a nanoplatform to conjugate covalently an anticancer drug, alpha-tocopheryl succinate (α-Tos) and targeting ligand folic acid (FA). The formed multifunctional dendrimers are able to endow the hydrophobic drug α-Tos with improved water solubility for targeted inhibition of cancer cells via an FA receptor-mediated targeting pathway.

Graphical abstract: Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy

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Article information

DOI
https://doi.org/10.1039/C3MD00324H
Article type
Concise Article
Submitted
27 Oct 2013
Accepted
28 Jan 2014
First published
29 Jan 2014

Med. Chem. Commun., 2014,5, 879-885

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Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy

Y. Zheng, F. Fu, M. Zhang, M. Shen, M. Zhu and X. Shi, Med. Chem. Commun., 2014, 5, 879 DOI: 10.1039/C3MD00324H

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