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Issue 3, 2014
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Bioluminescence: a versatile technique for imaging cellular and molecular features

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Abstract

Bioluminescence is a ubiquitous imaging modality for visualizing biological processes in vivo. This technique employs visible light and interfaces readily with most cell and tissue types, making it a versatile technology for preclinical studies. Here we review basic bioluminescence imaging principles, along with applications of the technology that are relevant to the medicinal chemistry community. These include noninvasive cell tracking experiments, analyses of protein function, and methods to visualize small molecule metabolites. In each section, we also discuss how bioluminescent tools have revealed insights into experimental therapies and aided drug discovery. Last, we highlight the development of new bioluminescent tools that will enable more sensitive and multi-component imaging experiments and, thus, expand our broader understanding of living systems.

Graphical abstract: Bioluminescence: a versatile technique for imaging cellular and molecular features

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Article information


Submitted
30 Sep 2013
Accepted
18 Nov 2013
First published
13 Dec 2013

, 2014,5, 255-267
Article type
Review Article

Bioluminescence: a versatile technique for imaging cellular and molecular features

M. A. Paley and J. A. Prescher, , 2014, 5, 255
DOI: 10.1039/C3MD00288H

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