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Issue 8, 2013
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Chemical motifs that redox cycle and their associated toxicity

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Abstract

Focussed screening of known redox cyclers, and structurally related compounds, was performed using a horseradish peroxidase–phenol red (hydrogen peroxide) assay. A cell viability assay was then used to further understand structure-based toxicity. Pyrimidotriazinediones were confirmed as structural alerts and new redox cycling motifs were identified.

Graphical abstract: Chemical motifs that redox cycle and their associated toxicity

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Publication details

The article was received on 29 May 2013, accepted on 29 Jun 2013 and first published on 01 Jul 2013


Article type: Concise Article
DOI: 10.1039/C3MD00149K
Med. Chem. Commun., 2013,4, 1175-1180

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    Chemical motifs that redox cycle and their associated toxicity

    P. Rana, R. Naven, A. Narayanan, Y. Will and L. H. Jones, Med. Chem. Commun., 2013, 4, 1175
    DOI: 10.1039/C3MD00149K

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