Issue 1, 2013

Small molecules aimed at type III secretion systems to inhibit bacterial virulence

Abstract

The development of new anti-bacterial compounds presents a major challenge to modern medicine as bacterial strains resistant to traditional antibiotics are constantly emerging. Type III secretion systems (T3SSs) are essential for virulence mechanisms of many Gram-negative bacterial pathogens and have therefore emerged as an attractive target for small molecule anti-virulence therapeutics. This has led to several high-throughput screens in search for specific chemicals that inhibit the secretion and translocation of bacterial effectorproteins. Several classes of small molecules have now been identified from these screens and this review focuses on their discovery and discusses their potential mechanisms of action and prospects for clinical development.

Graphical abstract: Small molecules aimed at type III secretion systems to inhibit bacterial virulence

Article information

Article type
Review Article
Submitted
27 Jul 2012
Accepted
13 Sep 2012
First published
14 Sep 2012

Med. Chem. Commun., 2013,4, 68-79

Small molecules aimed at type III secretion systems to inhibit bacterial virulence

L. K. Tsou, P. D. Dossa and H. C. Hang, Med. Chem. Commun., 2013, 4, 68 DOI: 10.1039/C2MD20213A

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