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Issue 1, 2013
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Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

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Abstract

Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.

Graphical abstract: Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

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Supplementary files

Article information


Submitted
21 Jun 2012
Accepted
20 Jul 2012
First published
13 Aug 2012

Med. Chem. Commun., 2013,4, 120-124
Article type
Concise Article

Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

I. M. Herzog, M. Feldman, A. Eldar-Boock, R. Satchi-Fainaro and M. Fridman, Med. Chem. Commun., 2013, 4, 120
DOI: 10.1039/C2MD20162C

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