Issue 12, 2012

Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges

Abstract

4-Chlorocolchicine derivatives were synthesized with a view of developing new anticancer agents. The derivatives were examined for their potent activities and effective dosage ranges in mice, as well as favorable metabolic stabilities. As a result, derivatives 37 and 40, bearing an α-hydroxyalkanoyl group on the C-7 amino function, were revealed to exhibit potent activities with broad effective dosage ranges.

Graphical abstract: Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges

Supplementary files

Article information

Article type
Concise Article
Submitted
23 Aug 2012
Accepted
27 Sep 2012
First published
01 Oct 2012

Med. Chem. Commun., 2012,3, 1500-1504

Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges

H. Nishiyama, M. Ono, T. Sugimoto, T. Sasai, N. Asakawa, T. Yaegashi, M. Nagaoka, T. Matsuzaki, N. Kogure, M. Kitajima and H. Takayama, Med. Chem. Commun., 2012, 3, 1500 DOI: 10.1039/C2MD20250F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements