Issue 11, 2012
From the journal:

MedChemComm

The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors†

Erick A. Lindsey,a   Christopher M. Brackett,a   Trey Mullikin,a   Cristina Alcaraza  and  Christian Melander*a  

* Corresponding authors

a Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA
E-mail: ccmeland@ncsu.edu
Fax: +1 919-515-5079
Tel: +1 919-513-2960

Abstract

A diverse 23-compound library of N-1 substituted 2-aminobenzimidazoles was synthesized via an efficient three-step process. This small library produced several non-toxic biofilm modulators of two strains of MRSA. Preliminary mechanistic studies reveal a zinc-dependent mode of action for these compounds.

Graphical abstract: The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors

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Article information

DOI
https://doi.org/10.1039/C2MD20244A
Article type
Concise Article
Submitted
17 Aug 2012
Accepted
18 Sep 2012
First published
24 Sep 2012

Med. Chem. Commun., 2012,3, 1462-1465

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The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors

E. A. Lindsey, C. M. Brackett, T. Mullikin, C. Alcaraz and C. Melander, Med. Chem. Commun., 2012, 3, 1462 DOI: 10.1039/C2MD20244A

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