Issue 10, 2012
From the journal:

MedChemComm

Mannich- and Lederer–Manasse-based analogues of the natural product S-(+)-curcuphenol as cancer proliferation and migration inhibitors†

Fathy A. Behery,a   Asmaa A. Sallama  and  Khalid A. El Sayed*a  

* Corresponding authors

a Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71201, USA
E-mail: elsayed@ulm.edu
Fax: +1 3183421737
Tel: +1 3183421725

Abstract

The Mannich-based analogues of S-(+)-curcuphenol (1), 3a–5a, and 3b potently inhibited the growth of several NCI's human cancer cell lines. In addition, 7a showed a 12-fold antimigratory activity (IC50 3.1 μM) against the human breast cancer cell line MDA-MB-231 compared to its parent 1 (IC50 37.2 μM).

Graphical abstract: Mannich- and Lederer–Manasse-based analogues of the natural product S-(+)-curcuphenol as cancer proliferation and migration inhibitors

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Article information

DOI
https://doi.org/10.1039/C2MD20185B
Article type
Concise Article
Submitted
04 Jul 2012
Accepted
14 Aug 2012
First published
20 Aug 2012

Med. Chem. Commun., 2012,3, 1309-1315

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Mannich- and Lederer–Manasse-based analogues of the natural product S-(+)-curcuphenol as cancer proliferation and migration inhibitors

F. A. Behery, A. A. Sallam and K. A. El Sayed, Med. Chem. Commun., 2012, 3, 1309 DOI: 10.1039/C2MD20185B

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