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Issue 11, 2012
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‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

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Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka TamifluTM) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Graphical abstract: ‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

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Article information


Submitted
07 Feb 2012
Accepted
06 May 2012
First published
09 May 2012

Med. Chem. Commun., 2012,3, 1373-1376
Article type
Concise Article

‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

M. Stanley, N. Cattle, J. McCauley, S. R. Martin, A. Rashid, R. A. Field, B. Carbain and H. Streicher, Med. Chem. Commun., 2012, 3, 1373
DOI: 10.1039/C2MD20034A

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