Issue 7, 2012
From the journal:

MedChemComm

Preliminary in vitro evaluation of N′-(benzofuroxan-5-yl)methylene benzohydrazide derivatives as potential anti-Trypanosoma cruzi agents†

Salomão Dória Jorge,*a   Marina Ishii,a   Fanny Palace-Berl,a   Adilson Kleber Ferreira,b   Paulo Luiz de Sá Júnior,b   Alex Alfredo de Oliveira,a   Ieda Yuriko Sonehara,a   Kerly Fernanda Mesquita Pasqualotoa  and  Leoberto Costa Tavaresa  

* Corresponding authors

a Departamento de Tecnologia Bioquímico Farmacêutica, Faculdade de Farmácia, Universidade de São Paulo, Av. Prof Lineu Prestes, 580, São Paulo, SP 05508-900, Brazil
E-mail: sdjorge@usp.br, sdjorge@gmail.com
Fax: +55 11 38156386
Tel: +55 11 30913693

b Laboratorio de Genética, Instituto Butantan, São Paulo, SP 05503-900, Brazil

Abstract

A set of benzofuroxan derivatives was tested in vitro against Trypanosoma cruzi epimastigote forms. The influence of physicochemical properties on these benzofuroxan derivatives' activity was observed, and the presence of electron-withdrawing and hydrophobic groups attached to the benzene ring seems to make a favorable contribution at lower concentrations.

Graphical abstract: Preliminary in vitro evaluation of N′-(benzofuroxan-5-yl)methylene benzohydrazide derivatives as potential anti-Trypanosoma cruzi agents

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Article information

DOI
https://doi.org/10.1039/C2MD20019H
Article type
Concise Article
Submitted
26 Jan 2012
Accepted
16 Apr 2012
First published
19 Apr 2012

Med. Chem. Commun., 2012,3, 824-828

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Preliminary in vitro evaluation of N′-(benzofuroxan-5-yl)methylene benzohydrazide derivatives as potential anti-Trypanosoma cruzi agents

S. D. Jorge, M. Ishii, F. Palace-Berl, A. K. Ferreira, P. Luiz de Sá Júnior, A. Alfredo de Oliveira, I. Y. Sonehara, K. F. M. Pasqualoto and L. C. Tavares, Med. Chem. Commun., 2012, 3, 824 DOI: 10.1039/C2MD20019H

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