Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors†
Abstract
Signal Transducer and Activator of Transcription 3 (STAT3) is a latent cytoplasmic
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* Corresponding authors
a
Dipartimento di Scienze Farmaceutiche “P. Pratesi”, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milano, Italy
E-mail:
arianna.gelain@unimi.it
Fax: +39-02-503-19359
Tel: +39-02-503-19369
b
Dipartimento di Chimica, Università degli Studi di Pavia, Via Taramelli 12, 27100 Pavia, Italy
E-mail:
laura.legnani@unipv.it
Fax: +39-0382-98-7323
Tel: +39-0382-98-7311
c Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience & Biotechnology and Department of Biomolecular Science, Korea University of Science and Technology, Eoun-Dong, Yuseong-gu, Daejeon 305-333, South Korea
d Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan
Signal Transducer and Activator of Transcription 3 (STAT3) is a latent cytoplasmic
D. Masciocchi, S. Villa, F. Meneghetti, A. Pedretti, D. Barlocco, L. Legnani, L. Toma, B. Kwon, S. Nakano, A. Asai and A. Gelain, Med. Chem. Commun., 2012, 3, 592 DOI: 10.1039/C2MD20018J
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