Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase
Abstract
The inhibition of the soluble
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* Corresponding authors
a
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, China
E-mail:
yqlong@mail.shcnc.ac.cn
Fax: +86-21-50806876
Tel: +86-21-50806876
b Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, CA, USA
c School of Chemical Science and Technology, Yunnan University, Kunming, China
The inhibition of the soluble
S. Huang, B. Cao, C. Morisseau, Y. Jin, B. D. Hammock and Y. Long, Med. Chem. Commun., 2012, 3, 379 DOI: 10.1039/C2MD00288D
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