Issue 8, 2011
From the journal:

MedChemComm

Novel N-sulfonamide trans-platinum complexes: synthesis, reactivity and in vitro evaluation†

José Alemán,*a   Virginia del Solar,b   Amparo Alvarez-Valdés,b   Carla Ríos-Luci,c   José M. Padrónc  and  Carmen Navarro-Ranninger*b  

* Corresponding authors

a Departamento de Química Orgánica (C-1), Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain

b Departamento de Química Inorgánica (C-7), Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
Fax: +34 914974833

c Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, La Laguna, Spain
E-mail: jose.aleman@uam.es, carmen.navarro@uam.es

Abstract

In this work, we described for the first time the synthesis of trans-N-sulfonamide platinum complexes. The antiproliferative activity (GI50, μM) of these new compounds in human solid tumors cells was compared to cisplatin.

Graphical abstract: Novel N-sulfonamide trans-platinum complexes: synthesis, reactivity and in vitro evaluation

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Article information

DOI
https://doi.org/10.1039/C1MD00070E
Article type
Concise Article
Submitted
08 Mar 2011
Accepted
20 May 2011
First published
30 Jun 2011

Med. Chem. Commun., 2011,2, 789-793

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Novel N-sulfonamide trans-platinum complexes: synthesis, reactivity and in vitro evaluation

J. Alemán, V. del Solar, A. Alvarez-Valdés, C. Ríos-Luci, J. M. Padrón and C. Navarro-Ranninger, Med. Chem. Commun., 2011, 2, 789 DOI: 10.1039/C1MD00070E

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