Issue 7, 2011

Temocene: the porphycene analogue of temoporfin (Foscan®)

Abstract

Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.

Graphical abstract: Temocene: the porphycene analogue of temoporfin (Foscan®)

Supplementary files

Article information

Article type
Concise Article
Submitted
02 Mar 2011
Accepted
08 Apr 2011
First published
06 May 2011

Med. Chem. Commun., 2011,2, 616-619

Temocene: the porphycene analogue of temoporfin (Foscan®)

M. García-Díaz, D. Sánchez-García, J. Soriano, M. L. Sagristà, M. Mora, Á. Villanueva, J. C. Stockert, M. Cañete and S. Nonell, Med. Chem. Commun., 2011, 2, 616 DOI: 10.1039/C1MD00065A

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