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Issue 3, 2011
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Interactions of polysulfanes with components of red blood cells

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Abstract

Traditionally, the activity of most polysulfanes has been associated with the redox behaviour of the sulfur-sulfur bond. Here we show that polysulfanes, such as diallyltri- and tetrasulfide, also interact with cellular membranes and certain metalloproteins. Together, multiple interactions with various biological targets may explain best the biological activity of such compounds.

Graphical abstract: Interactions of polysulfanes with components of red blood cells

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Publication details

The article was received on 04 Nov 2010, accepted on 11 Dec 2010 and first published on 19 Jan 2011


Article type: Concise Article
DOI: 10.1039/C0MD00203H
Med. Chem. Commun., 2011,2, 196-200

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    Interactions of polysulfanes with components of red blood cells

    T. Schneider, L. A. Ba, K. Khairan, C. Zwergel, N. D. Bach, I. Bernhardt, W. Brandt, L. Wessjohann, M. Diederich and C. Jacob, Med. Chem. Commun., 2011, 2, 196
    DOI: 10.1039/C0MD00203H

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