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Issue 1, 2011
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Evaluation of FR901464 analogues in vitro and in vivo

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Abstract

This study was designed to determine the in vitro and in vivo antitumor behaviour of three analogues of the natural product FR901464. All analogues demonstrated effective inhibition of cell proliferation. Minimal in vivo antitumor activity was observed, warranting further PK and antitumor efficacy studies.

Graphical abstract: Evaluation of FR901464 analogues in vitro and in vivo

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Article information


Submitted
07 Oct 2010
Accepted
16 Oct 2010
First published
02 Nov 2010

Med. Chem. Commun., 2011,2, 38-43
Article type
Concise Article

Evaluation of FR901464 analogues in vitro and in vivo

S. Osman, W. R. Waud, G. S. Gorman, B. W. Day and K. Koide, Med. Chem. Commun., 2011, 2, 38
DOI: 10.1039/C0MD00179A

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