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Issue 3, 2010
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Photo-degradation of amyloid β by a designed fullerene–sugar hybrid

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Abstract

A purpose-designed fullerene–sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

Graphical abstract: Photo-degradation of amyloid β by a designed fullerene–sugar hybrid

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Publication details

The article was received on 09 Jun 2010, accepted on 07 Jul 2010 and first published on 04 Aug 2010


Article type: Concise Article
DOI: 10.1039/C0MD00075B
Citation: Med. Chem. Commun., 2010,1, 212-215

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    Photo-degradation of amyloid β by a designed fullerene–sugar hybrid

    Y. Ishida, S. Tanimoto, D. Takahashi and K. Toshima, Med. Chem. Commun., 2010, 1, 212
    DOI: 10.1039/C0MD00075B

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