Issue 1, 2010
From the journal:

MedChemComm

Fluorocarbon oligonucleotide conjugates for nucleic acids delivery†

Guilhem Godeau,ab   Hélène Arnion,ab   Christophe Brun,ab   Cathy Staedelab  and  Philippe Barthélémy*ab  

* Corresponding authors

a Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
E-mail: philippe.barthelemy@inserm.fr
Fax: +33 5 5757 1015
Tel: +33 5 5757 4853

b INSERM U869, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France

Abstract

Here we describe an automated synthetic pathway for the synthesis of fluorocarbon oligonucleotide conjugates (FONs) featuring fluorocarbon hydrophobic and lipophobic moieties. The presence of highly fluorinated chains allows the delivery of nucleic acids into human cells.

Graphical abstract: Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

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Article information

DOI
https://doi.org/10.1039/C0MD00054J
Article type
Concise Article
Submitted
22 Apr 2010
Accepted
18 May 2010
First published
04 Jun 2010

Med. Chem. Commun., 2010,1, 76-78

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Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

G. Godeau, H. Arnion, C. Brun, C. Staedel and P. Barthélémy, Med. Chem. Commun., 2010, 1, 76 DOI: 10.1039/C0MD00054J

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