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Issue 2, 2010
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Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates

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Abstract

Two cephalosporin-oxazolidinone conjugates were synthesized by incorporation of a carbamate linker at the 3′-position of the cephalosporin. These compounds show stability in aqueous media until specifically activated by a β-lactamase, and retain antibacterial activities profiles reflecting both the individual cephalosporin and oxazolidinone components.

Graphical abstract: Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates

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Publication details

The article was received on 18 Feb 2010, accepted on 31 Mar 2010 and first published on 05 May 2010


Article type: Concise Article
DOI: 10.1039/C0MD00015A
Citation: Med. Chem. Commun., 2010,1, 145-148
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    Syntheses and biological evaluation of new cephalosporin-oxazolidinone conjugates

    S. Yan, M. J. Miller, T. A. Wencewicz and U. Möllmann, Med. Chem. Commun., 2010, 1, 145
    DOI: 10.1039/C0MD00015A

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