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Issue 9, 2017
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Understanding the role of tyrosine in glycogenin

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Abstract

We explored the molecular basis of tyrosine as the docking amino acid for the first glucose molecule during the synthesis of glycogen. The IR spectra show that the aromatic ring acts as bait to keep the position where the next glucose unit has to bind clear, by luring non-desirable molecules towards the aromatic ring. Only, α-/β-glucose shows particular affinity for the O3H and O4H moieties.

Graphical abstract: Understanding the role of tyrosine in glycogenin

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Article information


Submitted
17 May 2017
Accepted
26 Jun 2017
First published
30 Jun 2017

Mol. BioSyst., 2017,13, 1709-1712
Article type
Communication

Understanding the role of tyrosine in glycogenin

A. Camiruaga, I. Usabiaga, A. Insausti, E. J. Cocinero, I. León and J. A. Fernández, Mol. BioSyst., 2017, 13, 1709 DOI: 10.1039/C7MB00293A

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