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Issue 10, 2016
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Exploring the origin of the catalytic power and product specificity of SET domain protein methyltransferase

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Abstract

Herein, we used computer simulation to evaluate the free energy activation barriers of the first and second methyl transfer for native SET8 PKMT and its Y334F mutant. The results suggest that the origin of SET8 catalytic power is mainly due to electrostatic preorganization.

Graphical abstract: Exploring the origin of the catalytic power and product specificity of SET domain protein methyltransferase

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Supplementary files

Article information


Submitted
26 May 2016
Accepted
21 Jul 2016
First published
21 Jul 2016

Mol. BioSyst., 2016,12, 2980-2983
Article type
Communication

Exploring the origin of the catalytic power and product specificity of SET domain protein methyltransferase

A. H. Lima, C. N. Alves, R. Prasad and J. Lameira, Mol. BioSyst., 2016, 12, 2980
DOI: 10.1039/C6MB00414H

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