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Issue 4, 2015
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Systems biology approach to understanding post-traumatic stress disorder

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Abstract

Post-traumatic stress disorder (PTSD) is a psychological disorder affecting individuals that have experienced life-changing traumatic events. The symptoms of PTSD experienced by these subjects—including acute anxiety, flashbacks, and hyper-arousal—disrupt their normal functioning. Although PTSD is still categorized as a psychological disorder, recent years have witnessed a multi-directional research effort attempting to understand the biomolecular origins of the disorder. This review begins by providing a brief overview of the known biological underpinnings of the disorder resulting from studies using structural and functional neuroimaging, endocrinology, and genetic and epigenetic assays. Next, we discuss the systems biology approach, which is often used to gain mechanistic insights from the wealth of available high-throughput experimental data. Finally, we provide an overview of the current computational tools used to decipher the heterogeneous types of molecular data collected in the study of PTSD.

Graphical abstract: Systems biology approach to understanding post-traumatic stress disorder

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Article information


Submitted
10 Jul 2014
Accepted
13 Jan 2015
First published
14 Jan 2015

Mol. BioSyst., 2015,11, 980-993
Article type
Review Article

Systems biology approach to understanding post-traumatic stress disorder

G. S. Thakur, B. J. Daigle Jr, K. R. Dean, Y. Zhang, M. Rodriguez-Fernandez, R. Hammamieh, R. Yang, M. Jett, J. Palma, L. R. Petzold and F. J. Doyle III, Mol. BioSyst., 2015, 11, 980
DOI: 10.1039/C4MB00404C

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