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Issue 10, 2014
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Effect of a Ru(ii) polypyridyl complex [Ru(bpy)2(mdpz)]2+ on the stabilization of the RNA triplex poly(U)·poly(A)*poly(U)

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Abstract

There is renewed interest in investigating triplex nucleic acids because triplexes may be implicated in a range of cellular functions. However, the stabilization of triplex nucleic acids is essential to achieve their biological functions. In contrast to triplex DNA, little has been reported concerning the recognition of triplex RNA by transition-metal complexes at present. We report here a ruthenium(II) polypyridyl complex, [Ru(bpy)2(mdpz)]2+ (bpy = 2,2′-bipyridine; mdpz = 7,7′-methylenedioxyphenyl-dipyrido-[3,2-a:2′,3′-c]phenazine), as a sensitive luminescent probe for poly(U)·poly(A)*poly(U), which can strongly stabilize the triplex RNA from 37.5 to 53.1 °C in solution. The main results further advance our knowledge on the triplex RNA-binding by metal complexes, particularly ruthenium(II) complexes.

Graphical abstract: Effect of a Ru(ii) polypyridyl complex [Ru(bpy)2(mdpz)]2+ on the stabilization of the RNA triplex poly(U)·poly(A)*poly(U)

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Publication details

The article was received on 19 May 2014, accepted on 30 Jun 2014 and first published on 02 Jul 2014


Article type: Paper
DOI: 10.1039/C4MB00304G
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Mol. BioSyst., 2014,10, 2552-2557

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    Effect of a Ru(II) polypyridyl complex [Ru(bpy)2(mdpz)]2+ on the stabilization of the RNA triplex poly(U)·poly(A)*poly(U)

    X. He, J. Li, H. Zhang and L. Tan, Mol. BioSyst., 2014, 10, 2552
    DOI: 10.1039/C4MB00304G

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