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Issue 8, 2013
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Metabolomic analysis of sun exposed skin

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Abstract

It is very well known that exposure of skin to sun chronically accelerates the mechanism of aging as well as making it more susceptible toward skin cancer. This aspect of aging has been studied very well through genomics and proteomics tools. In this study we have used a metabolomic approach for the first time to determine the differences in the metabolome from full thickness skin biopsies from sun exposed and sun protected sites. We have primarily investigated the energy metabolism and the oxidative pathway in sun exposed skin. Biochemical pathway analysis revealed that energy metabolism in photoexposed skin is predominantly anaerobic. The study also validated the increased oxidative stress in skin.

Graphical abstract: Metabolomic analysis of sun exposed skin

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Supplementary files

Article information


Submitted
22 Nov 2012
Accepted
10 Apr 2013
First published
16 Apr 2013

Mol. BioSyst., 2013,9, 2045-2050
Article type
Paper

Metabolomic analysis of sun exposed skin

M. Randhawa, M. Southall and S. T. Samaras, Mol. BioSyst., 2013, 9, 2045
DOI: 10.1039/C3MB25537A

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