Issue 5, 2013

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Abstract

A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.

Graphical abstract: Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2012
Accepted
27 Nov 2012
First published
28 Nov 2012

Mol. BioSyst., 2013,9, 944-947

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Y. H. Ban, J. H. Lee, G. R. Gu, B. Lee, S. Mo, H. J. Kwon and Y. J. Yoon, Mol. BioSyst., 2013, 9, 944 DOI: 10.1039/C2MB25419K

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