Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 1, 2013
Previous Article Next Article

Identification of polyoxometalates as inhibitors of basic fibroblast growth factor

Author affiliations

Abstract

Angiogenesis is the process of new blood vessel formation from pre-existing ones. Angiogenic factors contribute to neovascularization that takes place in angiogenesis-dependent diseases, including cancer. Inhibiting the activity of the angiogenic factors to block the angiogenesis pathways is the current strategy of cancer therapy. Basic fibroblast growth factor (bFGF) is regarded as one of the most important angiogenic factors. Herein, we selected polyoxometalates (POMs) with different structures to study the interactions between bFGF and POMs. The results show that POMs could bind to the protein with high affinity, causing detectable changes in conformation and biophysical properties of protein. In addition, POMs could effectively inhibit the cell proliferation induced by bFGF. Significantly, we found that the structure, size and composition of POMs play a key role in the interactions between bFGF and POMs. This study will be meaningful for future screening and design of polyoxometalate-based anticancer drugs.

Graphical abstract: Identification of polyoxometalates as inhibitors of basic fibroblast growth factor

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 May 2012, accepted on 12 Oct 2012 and first published on 19 Oct 2012


Article type: Paper
DOI: 10.1039/C2MB25389E
Citation: Mol. BioSyst., 2013,9, 113-120

  •   Request permissions

    Identification of polyoxometalates as inhibitors of basic fibroblast growth factor

    F. Pu, E. Wang, H. Jiang and J. Ren, Mol. BioSyst., 2013, 9, 113
    DOI: 10.1039/C2MB25389E

Search articles by author

Spotlight

Advertisements