Issue 5, 2013
From the journal:

Molecular BioSystems

Tissue specific delivery of estrone-conjugated siRNAs†

Eun-Kyoung Bang,a   Eun Mi Jeon,a   Wanil Kim,b   Kyung-Ha Lee,b   Kyong-Tai Kim*b  and  Byeang Hyean Kim*a  

* Corresponding authors

a Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Korea
E-mail: bhkim@postech.ac.kr
Fax: +82 54 279 3399
Tel: +82 54 279 2115

b Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea
E-mail: ktk@postech.ac.kr

Abstract

An estrone phosphoramidite, synthesized in a single step, was directly incorporated at the 5′ ends of small interfering RNAs (siRNAs). The resulting estrone-conjugated siRNAs readily pass through cellular membranes and down-regulate the target protein, and show specific distributions in vivo.

Graphical abstract: Tissue specific delivery of estrone-conjugated siRNAs

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2MB25258A
Article type
Paper
Submitted
29 Jun 2012
Accepted
05 Sep 2012
First published
06 Sep 2012

Mol. BioSyst., 2013,9, 974-977

Permissions

Request permissions

Tissue specific delivery of estrone-conjugated siRNAs

E. Bang, E. M. Jeon, W. Kim, K. Lee, K. Kim and B. H. Kim, Mol. BioSyst., 2013, 9, 974 DOI: 10.1039/C2MB25258A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements