Issue 10, 2012

Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders

Abstract

Psychiatric disorders affect approximately 10% of adults in North-America. The complex nature of these illnesses makes the search for their pathophysiology a challenge. However, studies have consistently shown that mitochondrial dysfunction and oxidative stress are common features across major psychiatric disorders, including bipolar disorder and schizophrenia. Nevertheless, little is known about specific targets of oxidation in the brain. The search for redox sensors (protein targets for oxidation) will offer information about which pathways are regulated by oxidation in psychiatric disorders. Additionally, DNA is also a target for oxidative damage and recently, studies have suggested that oxidation of cytosine and guanosine can serve as an epigenetic modulator by decreasing or preventing further DNA methylation. Therefore, this review aims to discuss how we can use redox-proteomics and epigenomics to help explain the role of oxidative damage in major psychiatric disorders, which may ultimately lead to the identification of targets for development of new medications.

Graphical abstract: Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders

Article information

Article type
Review Article
Submitted
27 Mar 2012
Accepted
10 May 2012
First published
18 Jun 2012

Mol. BioSyst., 2012,8, 2503-2512

Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders

A. C. Andreazza, Mol. BioSyst., 2012, 8, 2503 DOI: 10.1039/C2MB25118C

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