Issue 7, 2011

Metabolomics study of diabetic retinopathy using gas chromatography–mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine

Abstract

Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and is one of the most frequent causes of blindness in the world. It has three progressive stages with complex metabolic deregulations in the holistic system of Western medicine. Chinese medicine classifies DR into two different syndrome types; integrating Western and Chinese medicine to treat DR is a validated therapeutic approach in China. In this research, the systemic metabolite change of DR was investigated from the viewpoint of both Western and Chinese medicine, using metabolomics based on gas chromatographymass spectrometry. The data revealed both perspectives can reflect the metabolic patterns, development and differentiation of DR, and the data also had good correlation and complementarity in characterizing the process of DR. Potential biomarkers of DR based on the two perspectives indicated the alterative modes of metabolites and metabolic pathways in the disease, e.g. the disturbance in fatty acids, amino acids and glucose, etc. The results showed the usefulness and validity of combining both Western and Chinese medicine to study the subtypes of DR and the mechanisms involved.

Graphical abstract: Metabolomics study of diabetic retinopathy using gas chromatography–mass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine

Supplementary files

Article information

Article type
Paper
Submitted
19 Dec 2010
Accepted
01 Apr 2011
First published
11 May 2011

Mol. BioSyst., 2011,7, 2228-2237

Metabolomics study of diabetic retinopathy using gas chromatographymass spectrometry: a comparison of stages and subtypes diagnosed by Western and Chinese medicine

X. Li, X. Luo, X. Lu, J. Duan and G. Xu, Mol. BioSyst., 2011, 7, 2228 DOI: 10.1039/C0MB00341G

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