Issue 3, 2011
From the journal:

Molecular BioSystems

Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa†

Amit Kumar,a   Satya S. Kolar,b   Meriong Zao,a   Alison M. McDermottb  and  Chengzhi Cai*a  

* Corresponding authors

a Department of Chemistry, University of Houston, Houston, TX 77204, USA

b College of Optometry, University of Houston, Houston, TX 77204, USA
E-mail: cai@uh.edu

Abstract

Antimicrobial peptide IG-25 (a truncated version of LL-37 of the cathelicidin family) tethering an azido-capped poly(ethylene glycol) chain at the N-terminus was site-specifically attached to alkynyl-terminated polymerized liposomes using copper catalyzed “click” reaction, leading to an 18 fold enhancement in efficacy against Pseudomonas aeruginosa when compared to LL-37 without any increase in cytotoxicity to human corneal epithelial cells.

Graphical abstract: Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa

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Article information

DOI
https://doi.org/10.1039/C0MB00207K
Article type
Communication
Submitted
24 Sep 2010
Accepted
13 Dec 2010
First published
13 Jan 2011

Mol. BioSyst., 2011,7, 711-713

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Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa

A. Kumar, S. S. Kolar, M. Zao, A. M. McDermott and C. Cai, Mol. BioSyst., 2011, 7, 711 DOI: 10.1039/C0MB00207K

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