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Issue 3, 2011
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Down-regulation of Prdx6 contributes to DNA vaccine induced vitiligo in mice

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Abstract

DNA vaccines are widely used against infectious agents for their ability to induce both humoral and cellular immune responses. However, safety concerns regarding autoimmune responses to DNA vaccines, particularly to certain plasmids, should not be neglected. In this study, we serendipitously found that mice inoculated with pcDNA3-ANXB1 (pcDNA3-b1) developed autoimmunity, which did not happen in pVAX-ANXB1 (pVAX-b1) inoculated mice. We also employed proteomics approaches to investigate the distinction between the two groups of DNA vaccine immunized mice. Five different proteins with three-fold or greater changes were separated and identified by two-dimensional electrophoresis. Our study verified the safety of the DNA vaccine and unveiled the underlying potential molecular mechanism of DNA vaccine delivery.

Graphical abstract: Down-regulation of Prdx6 contributes to DNA vaccine induced vitiligo in mice

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Article information


Submitted
28 Aug 2010
Accepted
13 Oct 2010
First published
10 Dec 2010

Mol. BioSyst., 2011,7, 809-816
Article type
Paper

Down-regulation of Prdx6 contributes to DNA vaccine induced vitiligo in mice

Q. Zhou, F. Wang, Y. Zhang, F. Yang, Y. Wang and S. Sun, Mol. BioSyst., 2011, 7, 809
DOI: 10.1039/C0MB00181C

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