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Issue 4, 2010
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Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

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Abstract

Site directed mutations of the C-methyltransferase domain of squalestatin tetraketide synthase were made in an attempt to alter the methylation pattern of the synthase expressed in vivo: mutation resulted in either no effect or in complete abrogation of polyketide production.

Graphical abstract: Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

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Article information


Submitted
16 Nov 2009
Accepted
21 Dec 2009
First published
10 Feb 2010

Mol. BioSyst., 2010,6, 680-682
Article type
Communication

Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

E. J. Skellam, D. Hurley, J. Davison, C. M. Lazarus, T. J. Simpson and R. J. Cox, Mol. BioSyst., 2010, 6, 680
DOI: 10.1039/B923990A

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